m.Prolozone Therapy Course


Modified Prolozone Therapy (m.Prolozone Therapy) is a non-surgical, non-invasive procedures where injectables including medical grade ozone gas are placed in the superficial dermis where they diffuse.

We do not teach or educate practitioners in Classic Prolozone Therapy using intra-articular injections combined with injectables directly into the joint itself which, should be done in an appropriate setting using scanning or ultrasound guidance.

m.Prolozone Therapy is applied using specific injection techniques and can support a range of patient management outcomes. Thereby, contributing to the overall well-being of a patient to cope with pain, whether it's in the form of acute or chronic symptoms. The net result improves the quality of life and the psychological impact associated from chronic pain

Course Accreditation

We are pleased to announce that The Medical Ozone Research Institute is the 1st Educational & Training Institute in the field of Medical Ozone Therapy to be accredited in the UK.

The Medical Ozone Research Institute is a Registered CPD Provider with the CPD Accreditation Group.
One of the most respected CPD Bodies in the UK.

The Propozone Therapy Course Certificate is Awarded 33 CPD Credits.

Who Can Apply

Medical Doctors GMC Registered


Prescribed Nurses

RGN’s that are supervised by a trained medical doctor who is on-site.

Registration Process

To register, fill out and complete registration form.
All practitioners are required to scan the following in a PDF format:
Passport ID
Proof of Address - e.g. Driving License, Bank Statement or Utility Bill
Medical Degree Certificate
Summary of your work experience and specialisation including any work with Ozone Therapy.
Once completed and your registration has been successful, a registration payment link will be sent to your email address.

Contact Us

You can contact us directly by using your mobile device on WhatsApp. If using your Desktop/Laptop or Tablet device please go to your WhatsApp on your mobile device and select the settings icon. Then select WhatsApp Web App/Desktop, then select QR Code. Now go to the WhatsApp Icon below and select the chat and a QR Code will load onto another browser tab. Scan the code and the chat will begin. If you are browsing on a mobile device, the WhatsApp Application will prompt you to open WhatsApp to start the chat for your registration.

Here you will be able to have a live chat and drop your documents directly into the chat for review.

Alternatively you can email your documents to:

Complete Registration Form

Registration Fees

Prolozone Therapy Course

Registration Fee: £2500

Full Payment of Registration Fees can be paid by Direct Debit or Credit/Debit Card.
Credit/Debit card payments will incur additional admin fees

Payment Plan Options:
To qualify you must be a UK, EU or USA Registered Citizen and have a bank account
A 50% deposit is required from the total registration fee
Instalments from 3 to 6 monthly payments are available
Payments are paid via Direct Debit
A Payment Plan Agreement will be sent to you to sign

International Payments:
Must be paid in full unless specified in the Payment Plan Option section, see above.

T&C apply

Additional Information

Prolozone Therapy

All practitioners will require the following additional certification:

First Aid Certificate
Medical Oxygen Gas Handling and Safety Certificate
List of course providers given upon registration.

Ozone Society
Professional Regulatory Body for Ozone Therapy Practitioners.
It ensures that all members are compliant to all areas of good practice, health and safety together with a code of conduct and a code of ethics to perform Ozone Therapy in the UK.

All members receive a certificate of membership, with an Ozone Society Seal for members website, PR and Marketing material. The Ozone Society has a public membership page where members can advertise their clinics.

Already Completed Medical Ozone Theory

Practitioners who have already completed a Clinical Ozone Therapy Course with the Institute, can directly register onto the Live Practical Courses. All applicants must send a PDF file of their current Clinical Ozone Therapy Course Certificate issued by the Institute.

Please send Clinical Ozone Therapy Course Certificate to admin(at)medicalozoneresearchinstitute.org

Once completed a registration payment link for the Live Practical Course will be sent via email.

m.Prolozone Therapy Course Information

Online Medical Ozone Theory

Focused Refresh

In this module we review several major biological pathways that interact and enable medical ozone to activate, modulate and upregulate specific pathway that involve our immune system, blood, blood circulation, antioxidant enzyme system and how some of these pathways can affect systemic pathogens. Additionally, we take a look into pathways involved in gut health and the microbiome.

Oxidative Stress and Antioxidants

Reactive Oxygen Species, Lipid Oxidative Products, Bio-messengers, Antioxidant Enzyme System and the rebalance of oxidative stress are reviewed and analysed in this module. Here we learn how a mild and transient oxidative stress can benefit the biological system.

Medical Ozone History

From the time when ozone gas was discovered to the innovators that developed the technology and use of ozone gas in medicine and dentistry. In the time-line, ozone technology, R&D and it's applications started in the USA. A change in American drug policy stopped R&D in ozone in it's tracks.

Ozone Physical & Chemical Properties | Types of Ozone Gas

The chemical and physical properties enable us to understand the qualities that ozone gas possess and why it behaves under specific condition. What are the different types of ozone gases, their functions, purity and the effect on earth and on humans.

Mechanism of Action Part 1 - 7

Here we look at the knowledge base and how ozone can influence specific mechanism of action at a cellular level. We study how ozone can destroy pathogens, the processes involved. We look at the red blood cell, immune cells and anti-oxidant enzymes play a specific role in providing the therapeutic properties ozone has on the body. How ozone naturally co-exists within an existing biochemical process of the body

Data and Graphs Part 1 - 4

We examine a range of peer review studies that support the research and clinical studies that determine the four main properties of medical ozone and it affect on biological systems.

Data | Further Research & Analysis

In this module research papers have been selected for you to download, to deepen your knowledge base. Some of these papers are focused on the interaction of medical ozone in the mitochondria, the respiratory burst, the immune system and viral interaction. Each peer review paper here can be used to cross reference and reinforce our understaning of the mechanism of action of ozone therapy and its properties on the biological system.

Indications and Applications

We look at what condition’s ozone can assist therapeutically; which applications are used to treat them, and which protocols produce an effective outcome for the client.

Methods of Application Part 1 - 3

We investigate each type of treatment application in ozone therapy. We distinguish between clinical and non-clinical treatments and how they compare to each other and what conditions and parameters each are best suited to the client.

Contra-Indications & Applications

Contra-indications are on the experience and current clinical data that indicate a risk vs therapeutic effect. There are some conditions where Ozone Therapy should not be applied. Applications that appear to have a robust therapeutic effect may have a high risk of patient safety.

Nutrition & Supplements Part 1 - 2

Nutrients are essential we using ozone therapy. How nutrient plays a vital role and how we can support the cellular function when using ozone therapy with nutrition and supplementation. We look at which types of supplement and the quality of supplements used to achieve the best results.

Medical Ozone Theory Final Exam

An exam will take place with an external auditor. The examination is done online, and can be done at your convenience, at your home or office. You have 2 hours to complete the exam and all practitioners have to obtain 70% or more to successfully pass this section of the course.

Online Medical Ozone Technical & Practical Training

Clinical Medical Ozone Technical & Practical Introduction

This is a prerequisite before coming to the Live Practical Training course which is face to face. Here we provide an overview of the importance of understanding the technical aspects of equipment, accessories and consumables for professional medical ozone therapy.

Ozone Generator

We cover a basic ozone generator, how it works, the parameters involved that have to meet, the production of ozone gas and these can be adjusted.

Oxygen Cylinders

The types of oxygen cylinder and master value connection, storage and health and safety requirement and compliance regulations involved.

Ozone Generator Accessories

The various accessories that can be used to widen the application of medical ozone therapy treatment applications.

Sedecal Certified Medical Device Ozone Generators

The Sedecal ozone generator systems, setup, operational modes and treatment applications that can be applied by this unit.

Live Practical Training | 1 Day Intensive

Medical Ozone Biochemistry in Prolozone

- Biochemistry in severe oxidative stress
- Biochemistry in moderate oxidative stress
- Medical Ozone in Inflammation
- Medical Ozone in Joints
- We review the therapeutic outcomes in each biochemical model.

The Arthritic Syndromes

- Rheumatoid Arthritis
- Osteoarthritis
- Juvenile Arthritis
- Symptoms and Examination - Standard Practice
- Alternative Practice

Protocols for Each Application

- General wellbeing protocols
- Frequency
- Duration of Protocols
- Ozone Concentrations
- Ozone Gas Volumes
- Patient Compliancy to Treatment Management

4 Types of Prolozone Injections

Here the range of techniques are shown and discussed and how each of them can be used individually and in combinations. Each technique has a specific use and function that we tailor for patient management.

Ozone Concentrations and Volumes

- supporting applications before and after ozone injections

Review and Analysis

Here we look at some videos where we discuss the client condition and focus on the areas that require specific observation. We monitor how the client's mobility and pain. Post- treatment, we see how efficient the treatment application has been and comparing pre and post specific observations, mobility and pain.

Diagnosis and Management

Once we have made our diagnoses, we take a look at the treatment management, which injections methods used and the injection points applied.


Live patient demonstrations with a range of conditions; this enables practitioners to examine, assess and interact with patients, to provide feedback and direct response to treatment. The number of demonstrations on the day are 4-8.

Ozone Generator
Prolozone Therapy
Is The

Comply with the European Cooperation Of Medical Ozone Socieities

Compliant with the Ozone Society


UK's Official Distributor | Medical Device Certified Ozone Generators 


CPD Accredited | The CPD Group

The Medical Ozone Research Institute Sponsors The Way of the Warriors

They are a group of veterans who have lived through the deep and soul-destroying effects of trauma after years in the field.

THE WAY OF THE WARRIORS blend ancient knowledge with modern research and naturopathic medicine. The Institute has trained their support team to provide additional care for the veterans recovery. To learn more, please visit their website: thewayofthewarriors.org

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admin@medicalozoneresearchinstitute.org | tel: 07798861406 |